Dr. Jhuma Bhadra

Dr. Jhuma Bhadra

DESIGNATION

Assistant Professor
Department of Chemistry

EMAIL

jbhadra.chem@sncwgs.ac.in

Orcid

0000-0002-3892-7333

Biography

Jhuma was born and raised in Kurumpur, a village under Sonamukhi (PS), Bankura where she completed her schooling. After high school, she went to Bankura Christian College for B.Sc (Chemistry Hons., 2008) and to Indian Institute of Technology (IIT) Kharagpur for M.Sc (Organic Chemistry Major, 2010). Later she joined Chembiotek (TCGLS, Kolkata) and worked there for 2 years. Then she moved to Indian Association for the Cultivation of Science to pursue her PhD. Jhuma then earned her PhD degree (2017) with Prof. Surajit Sinha, discovering synthesis and biological evaluation of morpholino antisense oligonucleotide. Inspired by her research experience, she joined to Clemson University, USA for Post-Doc with Prof. Dev P Arya where she used to synthesis morpholino antisense oligonucleotide for microbial and cancer gene inhibition (2017-2019). As an experienced and senior Post-Doc later she joined Boston College, USA with Prof. Jianmin Gao to explore peptide synthesis for bacterio-phage modification. Then Jhuma came back to India just before the COVID-19 and joined Prof. Santanu Bhattacharya (Director at IACS and Professor at IISC Bangalore) as DBT-RA where she has developed Nucleo-Lipid synthesis. After finishing her study and research she joined Kurseong college, Darjeeling as assistant professor at chemistry (2nd Sep, 2020) through CSC examination. Later on she has transferred to Kolkata and joined Sarojini Naidu College for Women on 30th April, 2022 and continuing her teaching.

Research

Dr. Bhadra has the following research interest

  • Design and synthesis of molecular transporter for drug delivery
  • Design, synthesis and evaluation of antisense efficacy of antisense oligonucleotide
  • Small molecule mediated hedgehog signaling pathway inhibition
  • Design and synthesis of aminoglycoside based antimicrobial agent

Currently, Dr. Bhadra is teaching the following courses:

  1. Organic Chemistry
  2. Green Chemistry
  3. Polymer Chemistry

Journal Articles

  1. Bose, C.; Das, U.; Kuilya, T. K.; Mondal, J.; Bhadra, J.; Banerjee, P.; Goswami, R. K.; Sinha S. (2022) Cananginone Abrogates EMT in Breast Cancer Cells through Hedgehog Signaling. Chemistry & Biodiversity, e202100823.
  2. Kundu, J.; Das, U.; Bose, C.; Bhadra, J.; Sinha, S. (2021) Self-transfecting GMO-PMO and PMO-GMO chimeras enable gene silencing in vitro and in vivo zebrafish model and NANOG Inhibition Induce the Apoptosis in Breast and Prostate Cancer Cells. bioRxiv- 2021
  3. Nandi, B.; Khatra, H.; Khan, P. P.; Bhadra, J.; Pattanayak, S.; Sinha, S. (2017) Cationic Cytosine Morpholino‐Based Transporters: Synthesis and Regulation of Intracellular Localization. ChemistrySelect 2, 5059-5067.
  4. Khatra, H.; Khan, P. P.; Pattanayak, S.; Bhadra, J.; Rather, B.; Chakrabarti, S.; Saha, T.; Sinha, S. (2018) Hedgehog Antagonist Pyrimidine–Indole Hybrid Molecule Inhibits Ciliogenesis through Microtubule Destabilisation. ChemBioChem 19, 723-735.
  5. Bhadra, J.; Pattanayak, S.; Khan, P. P.; Kundu, J.; Sinha, S. (2016) Internal oligoguanidinium-based cellular transporter enhances antisense efficacy of morpholinos in in vitro and zebrafish model. Bioconjugate chemistry 27, 2254-2259.
  6. Duttagupta, I.; Bhadra, J.; Das, S. K.; Sinha, S. (2016) Proteolytic stability of cyclic α-hydrazino acid containing peptides: a qualitative study. Tetrahedron letters 57, 3858-3861.
  7. Bhadra, J.; Kundu, J.; Ghosh, K. C.; Sinha, S. (2015) Synthesis of phosphorodiamidate morpholino oligonucleotides by H-phosphonate method. Tetrahedron letters 56, 4565-4568.
  8. Paul, S.; Jana, S.; Bhadra, J.; Sinha, S. (2013) Photophysical studies and submicron ring formation of morpholino U-nucleoside monomers. Chemical Communications 49, 11278-11280.
  9. Panda, B.; Bhadra, J.; Sarkar, T. K. (2011) An Approach to Highly Functionalized Quinolines and Isoquinolines via a Gold-Catalyzed Benzannulation. Synlett 2011, 689-693.

Book Chapters

  1. Bhadra, J.; Pattanayak, S.; Sinha, S. (2015) Synthesis of Morpholino Monomers, Chlorophosphoramidate Monomers, and Solid‐Phase Synthesis of Short Morpholino Oligomers. Current protocols in nucleic acid chemistry 62, 4.65. 1-4.65. 26.

  1. Sinha, S.; Bhadra, J.; Pattanayak, S.; Kundu, J. (2021) Oligo-guanidines based cellular transporter comprising heterocyclic rings with hydrophobic and/or lipophilic groups at N-terminal for effective delivery of nonpenetrable cargos in-vitro and in-vivo. US10919857B2

  1. NIH aided Boston College Postdoc Fellowship, Boston, Massachusetts, USA, 2019
  2. NIH aided Clemson UniversityPostdoc Fellowship, Clemson, South Carolina, USA, 2017
  3. Best Poster Award: In the Poster Competition On ‘Interface Between Chemistry and Biology’ organized By the Eastern India Section of The Royal Society Of Chemistry On 21st December, 2016, Indian Institute Of Chemical Biology, Kolkata, 2016
  4. Most Enthusiastic Participant Award: 15th Tetrahedron Symposium – Asia Edition, 28-31 October 2014, Singapore.
  5. International travel supports from Science and Engineering Research Board, Department of Science & Technology (SERB-DST), Government of India, 2014
  6. Qualified CSIR-UGC NET (Council for Scientific and Industrial Research-National Eligibility Test), 2013